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Muscle Tissue Organoids with Integrated Sensing
You will obtain functional constructs of living muscle tissue that can be implemented into robots as bio-actuators. The tissue will be realized via bioprinting or conventional biofabrication in 3D designs at the mm-to-cm scale. The deformation of the constructs will be achieved via electrical stimulation of contractile muscle cells, and integrated sensing elements will monitor the motion of the tissue constructs, improving functionality and autonomy. We will use granular hydrogels to develop sensing components to monitor the state of 3D organoids.
3D organoids are essential for studying how cells respond to different stimuli and drug development. Granular hydrogels combine high performance mechanical properties in swollen state and compatibility with 3D bioprinting. The goal of this project is to use granular hydrogels for the development of sensing components to monitor the state of 3D organoids. 3D Bioprinting will be used for the extrusion of the sensing materials a cell-laden bioink.
3D organoids are essential for studying how cells respond to different stimuli and drug development. Granular hydrogels combine high performance mechanical properties in swollen state and compatibility with 3D bioprinting. The goal of this project is to use granular hydrogels for the development of sensing components to monitor the state of 3D organoids. 3D Bioprinting will be used for the extrusion of the sensing materials a cell-laden bioink.
Within this project, you will develop resistive sensors based on granular hydrogels. 3D bioprinting will be used for integrating sensing elements in tissue engineered muscle constructs to develop 3D organoids. You will study the influence of the composition of the materials on the biocompatibility and their sensing properties. The sensorized organoids with a better perception of their internal state, contributing towards homeostasis and better monitoring of localized changes in 3D organoids
Within this project, you will develop resistive sensors based on granular hydrogels. 3D bioprinting will be used for integrating sensing elements in tissue engineered muscle constructs to develop 3D organoids. You will study the influence of the composition of the materials on the biocompatibility and their sensing properties. The sensorized organoids with a better perception of their internal state, contributing towards homeostasis and better monitoring of localized changes in 3D organoids
Dr. Miriam Filippi, mfilippi@ethz.ch, Soft Robotics Lab, Institute of Robotics and Intelligent Systems, D-MAVT.
Dr. Miriam Filippi, mfilippi@ethz.ch, Soft Robotics Lab, Institute of Robotics and Intelligent Systems, D-MAVT.