Biosensors and Bioelectronics (LBB)Open OpportunitiesScanning ion conductance microscopy (SICM) is the non-contact SPM technology to image live cells based on glass capillaries with a nanometric aperture. It applies a voltage and measures the ionic current flowing through the pipette above the sample in the buffer solution: the recorded current represents the feedback signal to measure the topography of the sample. In collaboration with Prof. Fantner at EPFL, this project aims to assemble a state of the art high-speed SICM to enable time-resolved live cell imaging. - Biomedical Engineering, Electrical and Electronic Engineering, Mechanical Engineering, Nanotechnology, Signal Processing
- Bachelor Thesis, Course Project, ETH Zurich (ETHZ), Lab Practice, Master Thesis, Summer School
| What about implantable self-powering devices to monitor biophysical signals at nanoscale? As a part of the interdisciplinary frontier between material science and new biomedical applications, being able to monitor biological or physical markers and signals, allows for a better treatment from both the diagnostic and healing point of view. Among them, biocompatible and non-intrusive wearable monitoring devices, which are so flexible to adhere perfectly to biological tissue, and even to cells like neurons, gain increasing interest. However, fabricating the devices and the electrodes at nano/microscale remains a challenge.
FluidFM is a force-controlled nanopipette, a versatile tool also for 2D patterning and 3D printing in liquid environment, opening the opportunity to manufacture the devices at the sub-micron scale.
We are going to create the devices and electrodes depositing conductive polymers with the FluidFM and then to perform the opportune characterization. - Electrical and Electronic Engineering, Materials Engineering, Medical and Health Sciences, Physics
- Master Thesis
| Pemphigus vulgaris (PV) is a unique group of autoimmune diseases. Researches have demonstrated that antibody-induced disruption of Dsg3 transadhesion initiates a signaling response in basal keratinocytes followed by loss of tissue integrity. The complexity of morphogenesis and tissue regeneration implies the existence of a transcellular communication network in which individual cells sense the environment and coordinate their biological activity in time and space.
To understand the fascinating ability of tissue self-organization, comprehensive study of biophysical properties (cell topography and bioelectricity) in combination with the analysis of biochemical networks (signaling pathways and genetic circuits) is required.
Together with the University of Bern and University of Lübeck, we aim to utilize the tools to study the topography and electrophysiology (cell potential, ion channel recording, localized ion detection, charges) of HPEK cells (human primary keratinocytes cells) to unravel the signaling pathways of the disease. We utilize optical imaging (fluorescence dyes) and biosensing tools (including the state of the art hs-SICM and electrical FluidFM setup) to study HPEK cells upon desmosome disruption.
- Biology, Biomedical Engineering, Chemistry, Electrical and Electronic Engineering, Interdisciplinary Engineering, Medical and Health Sciences
- Bachelor Thesis, Lab Practice, Master Thesis, Semester Project, Summer School
| You will develop a diagnostic test for testicular cancer. The focus of the project will be on creating the biochemical protocols for the test. The project is in collaboration with a prelaunch startup and a hospital (USZ). Therefore, it is ideal for motivated students who want to have a direct impact - Analytical Biochemistry, Biological and Medical Chemistry, Biomedical Engineering, Immunological and Bioassay Methods, Interdisciplinary Engineering, Materials Engineering, Sensor (Chemical and Bio-) Technology
- Bachelor Thesis, Internship, Lab Practice, Master Thesis, Semester Project, Summer School
| Collaborating with a dynamic startup, you will work on designing, manufacturing, and testing microfluidic devices to quantify biomolecules associated with chronic inflammation, heart attacks, and tropical diseases. - Biology, Biomedical Engineering, Chemical Engineering, Chemistry, Electrical and Electronic Engineering, Mechanical and Industrial Engineering, Medical and Health Sciences, Physics
- Bachelor Thesis, Collaboration, Internship, Lab Practice, Master Thesis, Semester Project, Summer School
| Join our interdisciplinary student project to transform at-home diagnostics! Work on cutting-edge technology, boost sensitivity, engineer tests for seamless home use, and develop targeted disease detection. Help us to shape the future of healthcare. - Biochemistry and Cell Biology, Biomedical Engineering, Chemical Engineering, Chemistry, Electrical Engineering, Fluidization and Fluid Mechanics, Materials Engineering, Mechanical Engineering, Medical and Health Sciences, Nanotechnology, Physics
- Bachelor Thesis, ETH Zurich (ETHZ), Lab Practice, Master Thesis, Semester Project, Summer School
| You will work on bringing medical tests to peoples home. You will further develop the hardware and software for a readout device that can perform a variety of diagnostic tests in a reliable but simple fashion. - Electrical and Electronic Engineering
- Bachelor Thesis, Internship, Lab Practice, Master Thesis, Semester Project, Summer School
| In this project, you will have the opportunity to contribute to the development and optimization of a single-molecule sensor designed for the detection, identification, and sequencing of important biomolecules such as DNA and proteins. The sensor technology is built upon the principles of microfluidics, nanofabrication, and machine-learning data analysis. It is an excellent fit for students who possess skills and a strong interest in these fields and are eager to engage in an interdisciplinary project with significant potential impact. - Biology, Chemistry, Engineering and Technology, Medical and Health Sciences, Physics
- Master Thesis
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