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Nanoglue for Wound Healing and Tissue Grafting
We offer a crossdisciplinary thesis project where you will develop a bioactive tissue glue for wound healing and tissue grafting applications.
Keywords: Wound healing, bioactive particles, cell culture, regenerative medicine
Wound healing is an extremely delicate process that involves a whole cascade of events, namely, hemostasis, sterilization, angiogenesis and wound remodelling. Perturbance of any of these steps in the healing cascade can lead to severe consequences, ranging from unsatisfactory aesthetic outcome to patient death from bacteraemia. Given the ever increasing burden of treating (chronic) wounds due to an aging population and increasing health care costs, there is a pressing clinical need for minimally invasive, integral wound care solutions for soft tissue injury, that are easy to handle, omit the necessity of suturing and support hemostasis and wound healing while keeping microbes and excessive myofibroblast invasion (causative for scarring/fibrosis) at bay.
The project will give you the opportunity to acquire a broad skill set ranging from nanoparticle synthesis and characterization, cell culture as well as various advanced imaging techniques (live cell confocal microscopy, electron microscopy). You can expect significant support and guidance from established scientists during the whole of your project. Work place will be the Empa St. Gallen with optional part-time stays at collaborating institutions in Zurich.
Wound healing is an extremely delicate process that involves a whole cascade of events, namely, hemostasis, sterilization, angiogenesis and wound remodelling. Perturbance of any of these steps in the healing cascade can lead to severe consequences, ranging from unsatisfactory aesthetic outcome to patient death from bacteraemia. Given the ever increasing burden of treating (chronic) wounds due to an aging population and increasing health care costs, there is a pressing clinical need for minimally invasive, integral wound care solutions for soft tissue injury, that are easy to handle, omit the necessity of suturing and support hemostasis and wound healing while keeping microbes and excessive myofibroblast invasion (causative for scarring/fibrosis) at bay.
The project will give you the opportunity to acquire a broad skill set ranging from nanoparticle synthesis and characterization, cell culture as well as various advanced imaging techniques (live cell confocal microscopy, electron microscopy). You can expect significant support and guidance from established scientists during the whole of your project. Work place will be the Empa St. Gallen with optional part-time stays at collaborating institutions in Zurich.
To develop a bioactive tisssue glue that supports wound healing.
To develop a bioactive tisssue glue that supports wound healing.
Dr. Inge Herrmann, Group Leader Particles 3D, Empa, inge.herrmann@empa.ch
Dr. Inge Herrmann, Group Leader Particles 3D, Empa, inge.herrmann@empa.ch