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Multiscale Correlative BioImaging
We offer a project where you will exploit the immense potential of a novel sample prepara-tion method to gain new insights into the realm of biochemistry and structure-function relations. You will build on promising pilot study data where we demonstrated that the new embedding procedure enables acqu
Keywords: BioImaing, Correlative Imaging, Structure-Function Relationships, 3D Tomography, Multiscale Imaging
Biological systems are vastly complex, and a better understanding of them heavily relies on our ability to see detailed relationships between structure and function at various levels of resolution and within a functional correlated context. Ever since the development of the first microscope, the study of biology and medicine has progressively increased its reliance on imaging methods. New techniques generated new possibilities, such as the visualization of proteins in cells and tissues, which has revolutionised our understanding of living systems. In order to unravel structure-function relationships, however, a correlative approach synergistically combining imaging information across scales is needed. Unfortunately, more often than not, a required sample preparation method makes a sample incompatible with other imaging methods and inadvertently creates a number of impediments to a full integration of the structural information of biological systems.
The project is strongly focused on exploiting the manifold opportunities of this novel method across different length scales in order to comprehensively demonstrate the added value to the growing field of (correlative) bioimaging. A key feature of the project is the simplicity and the elegance of the method that omits the need for specialized equipment hence opening correlative imaging to a much broader community of biomedical researchers.
This interdisciplinary thesis project gives you the opportunity to acquire a broad skill set ranging from biological specimen preparation to various advanced imaging techniques (confocal microscopy, electron microscopy and spectroscopy) and data analysis techniques. You can expect significant support and guidance from established scientists during the whole of your project. The project will be carried out in close collaboration with Dr Sergio Bertazzo from the Medical Physics Department at the University College London, UK. Work place will be the Empa St. Gallen.
Biological systems are vastly complex, and a better understanding of them heavily relies on our ability to see detailed relationships between structure and function at various levels of resolution and within a functional correlated context. Ever since the development of the first microscope, the study of biology and medicine has progressively increased its reliance on imaging methods. New techniques generated new possibilities, such as the visualization of proteins in cells and tissues, which has revolutionised our understanding of living systems. In order to unravel structure-function relationships, however, a correlative approach synergistically combining imaging information across scales is needed. Unfortunately, more often than not, a required sample preparation method makes a sample incompatible with other imaging methods and inadvertently creates a number of impediments to a full integration of the structural information of biological systems.
The project is strongly focused on exploiting the manifold opportunities of this novel method across different length scales in order to comprehensively demonstrate the added value to the growing field of (correlative) bioimaging. A key feature of the project is the simplicity and the elegance of the method that omits the need for specialized equipment hence opening correlative imaging to a much broader community of biomedical researchers.
This interdisciplinary thesis project gives you the opportunity to acquire a broad skill set ranging from biological specimen preparation to various advanced imaging techniques (confocal microscopy, electron microscopy and spectroscopy) and data analysis techniques. You can expect significant support and guidance from established scientists during the whole of your project. The project will be carried out in close collaboration with Dr Sergio Bertazzo from the Medical Physics Department at the University College London, UK. Work place will be the Empa St. Gallen.
To exploit the potential of a new imaging process for multiscale imaging (in collaboration with the Department of Medical Physics, UCL).
To exploit the potential of a new imaging process for multiscale imaging (in collaboration with the Department of Medical Physics, UCL).
Dr Inge Herrmann, Group Leader Particles 3D, Empa, inge.herrmann@empa.ch
Dr Inge Herrmann, Group Leader Particles 3D, Empa, inge.herrmann@empa.ch