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Development of novel and innovative molecular tools for bioactive functionalization of nanocellulose based coatings
A protein-engineering based approach is used to develop novel nanocellulose based bioactive coatings. The newly functionalized coatings will be evaluated on biochemical functionality and cytocompatibility to validate their potential in woundhealing application.
Keywords: Protein engineering, protein immobilization, molecular biology, bioengineering, materials sciences, cell material interaction, nanocellulose, surface characterization, microscopy
Project B: Nanocellulose based coatings have emerged great interest as functional wound
dressings and coatings mediating enhanced biocompatibility of implant materials. Smart molecular tools enabling orthogonal selective immobilization of bioactive ligands will be engineered, produced
and evaluated on their performance. A functional comparison of full cellulose binding domain (CBD)
tagged‐ vs functional cellulose binding peptide (CBP) tagged model ligands.
Project B: Nanocellulose based coatings have emerged great interest as functional wound dressings and coatings mediating enhanced biocompatibility of implant materials. Smart molecular tools enabling orthogonal selective immobilization of bioactive ligands will be engineered, produced and evaluated on their performance. A functional comparison of full cellulose binding domain (CBD) tagged‐ vs functional cellulose binding peptide (CBP) tagged model ligands.
The student will carry out the experimental workflow under regular supervision but will be
encouraged to develop and design his own approach. The student will contribute to the development
of molecular tools for bioactive functionalization of nanocellulose based coatings for smart wound
dressing applications. The projects will involve strong collaboration between the Laboratory for
Applied Wood Materials (Dübendorf/St.Gallen) and the Laboratory for Biointerfaces (St.Gallen) and
will include a diverse set of next‐gen analytical tools and presupposes the will to work in an
interdisciplinary environment.
The student will carry out the experimental workflow under regular supervision but will be encouraged to develop and design his own approach. The student will contribute to the development of molecular tools for bioactive functionalization of nanocellulose based coatings for smart wound dressing applications. The projects will involve strong collaboration between the Laboratory for Applied Wood Materials (Dübendorf/St.Gallen) and the Laboratory for Biointerfaces (St.Gallen) and will include a diverse set of next‐gen analytical tools and presupposes the will to work in an interdisciplinary environment.
Ramon Weishaupt
PhD Candidate
Empa
Swiss Federal Laboratories for Materials Science and Technology
Lerchenfeldstrasse 5
9014 St. Gallen
Switzerland
Tel +41 58 765 70 22
Fax +41 58 765 74 99
Ramon.weishaupt@empa.ch
www.empa.ch
Ramon Weishaupt PhD Candidate Empa Swiss Federal Laboratories for Materials Science and Technology Lerchenfeldstrasse 5 9014 St. Gallen Switzerland Tel +41 58 765 70 22 Fax +41 58 765 74 99 Ramon.weishaupt@empa.ch www.empa.ch